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Wearable devices possess excellent flexibility and can conform to irregular surfaces, extensively changing human healthcare fields. Ultrasonic technology, with its extensive penetration depth, nondestructive nature, and versatile functionalities, has been widely applied in the diagnosis and treatment of various diseases. However, traditional ultrasound devices are often bulky and rigid, significantly limiting their further development in the biomedical field. Wearable and flexible ultrasound devices combine the advantages of wearable electronics and ultrasound technology, providing real‐time, continuous, and nondestructive strategies for biomedical applications. Wearable ultrasound devices can seamlessly conform to human skin or organ surfaces, substantially enhancing working performance, durability, and comfort. Here, we review recent advancements in developing wearable ultrasound devices for biomedical applications, including materials, structural design, and applications in biomedical fields. We provide an overview of wearable ultrasound devices utilized for hemodynamics monitoring, deep‐tissue energy transmission, and closed‐loop therapy. Finally, we discuss existing challenges and future trends in developing wearable ultrasound devices.

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