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Review Article | Open Access

Hypoglycemic effects of edible fungus polysaccharides: A mini review

Yan-Long Cui1,2,3, Bo Li3( )
Postdoctoral Innovation Practice Base, Henan Institute of Science and Technology, Xinxiang 453000, China
Postdoctoral Research Center, Henan Bainong Seed Industry Co., Ltd. Xinxiang 453000, China
College of Food Science, Henan Institute of Science and Technology, Xinxiang 453000, China
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Highlights

(1) We summarize the hypoglycemic mechanisms of edible fungus polysaccharides (EFP).

(2) The structure-hypoglycemic activity relationship of EFP was fully discussed.

(3) We point out the probable future research directions and trends of EFP involved hypoglycemic effects.

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder with the feature of hyperglycemia, which has severely endangered human health. Edible fungus polysaccharides (EFP), which has great development potential, have attracted enormous attention since their natural and safe characteristics as well as obvious benefits against diabetes. This review summarized the hypoglycemic effect of EFP and the underlying mechanism against diabetes by inhibiting digestive enzyme activity, increasing insulin sensitivity and resistance, improving pancreatic function and lipid metabolism, alleviating oxidative stress and inflammation, regulating gut microbiota and signal transduction. In addition, the relationships between structure and hypoglycemic activity as well as future prospect of EFP were also discussed. This current review provides valuable insights for readers and healthcare professionals developing preventive and therapeutic of diabetes and development of functional products or foods of edible fungi in the future.

Graphical Abstract

Edible fungus are an important resource of food and medicine. Edible fungus Polysaccharides are one of the bioactive substances and own multiple biological activities, such as immunomodulatory, antioxidant, anti-inflammatory and hypoglycemic effect etc. The possible hypoglycemic mechanisms of edible fungus (EFP) were fully summarized.

Keywords

edible funguspolysaccharideshypoglycemic effectmechanisms

References

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Food & Medicine Homology
Volume 2 Issue 1,
March 2025
Article number: 9420046
DOI: 10.26599/FMH.2025.9420046

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Cite this article:
Cui Y-L, Li B. Hypoglycemic effects of edible fungus polysaccharides: A mini review. Food & Medicine Homology, 2025, 2(1): 9420046. https://doi.org/10.26599/FMH.2025.9420046

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Received: 28 June 2024
Revised: 10 July 2024
Accepted: 10 July 2024
Published: 28 September 2024
© National R & D Center for Edible Fungus Processing Technology 2024. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).