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Review | Open Access

Molecular mechanisms of cellular metabolic homeostasis in stem cells

Xiaoyu Li1 , Ou Jiang1, Songlin Wang1,2,3,4,5( )
Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, China
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Laboratory for Oral and General Health Integration and Translation, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Research Unit of Tooth Development and Regeneration, Chinese Academy of Medical Sciences, Beijing, China
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Abstract

Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets.

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International Journal of Oral Science
Volume 15,
2023
Article number: 52
DOI: 10.1038/s41368-023-00262-z

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Li X, Jiang O, Wang S. Molecular mechanisms of cellular metabolic homeostasis in stem cells. International Journal of Oral Science, 2023, 15: 52. https://doi.org/10.1038/s41368-023-00262-z

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Received: 02 November 2023
Revised: 12 November 2023
Accepted: 12 November 2023
Published: 01 December 2023
© The Author(s) 2023

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